The Age-Related Eye Disease Study (AREDS) was designed as both a study of the clinical course of AMD and lens opacities as well as a randomized controlled trial of high-dose antioxidants and zinc to reduce progression of these diseases. The results of AREDS revealed a statistically significant benefit of the combination of highdose antioxidant vitamins and zinc, providing a moderate reduction (34%) of the risk of developing advanced AMD over a median of 6.3 years of follow-up in persons at high risk of developing advanced AMD.
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