Descemet's Stripping Endothelial Keratoplasty Safety and Outcomes: A Report by the American Academy of Ophthalmology
Objective: To review the published literature on safety and outcomes of Descemet’s stripping endothelial keratoplasty (DSEK) for the surgical treatment of endothelial diseases of the cornea.
Conclusions: The evidence reviewed is supportive of DSEK being a safe and effective treatment for endothelial diseases of the cornea. In terms of surgical risks, complication rates, graft survival (clarity), visual acuity, and endothelial cell loss, DSEK appears similar to penetrating keratoplasty (PK). It seems to be superior to PK in terms of earlier visual recovery, refractive stability, postoperative refractive outcomes, wound and suture-related complications, and intraoperative and late suprachoroidal hemorrhage risk. The most common complications of DSEK do not appear to be detrimental to the ultimate vision recovery in most cases. Long-term endothelial cell survival and the risk of late endothelial rejection are beyond the scope of this assessment.
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